(2019) Nigerian propolis: chemical composition, antioxidant activity and α-amylase and α-glucosidase inhibition. Natural Product Research. ISSN 14786419 (ISSN)
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Abstract
Propolis is an attractive natural ingredient to design health products due to its pharmacological effects. Our chemical investigation of a polar extract of Nigerian propolis (NP) led the isolation and identification of five isoflavonoids (1-4, 6), one diarylpropane (5) and one prenylated flavanone (7) by the combination of chromatographic and spectroscopic techniques. Compounds 1, 4 and 7 were found to be the main markers in NP (8.0, 5.0 and 4.0 mg/g of dry extract, respectively). Moreover, NP and its phenolic constituents exhibited in vitro free radical scavenging activity together with a promising antidiabetic effect against α-amylase and α-glucosidase enzymes. Finally, NP showed also a moderate inhibition of Helicobacter pylori growth. These results suggested that NP could be a good candidate in nutraceuticals and food products. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
| Item Type: | Article |
|---|---|
| Keywords: | free-radical scavenging activity Helicobacter pylori Nigerian propolis polyphenols α-amylase and α-glucosidase enzymes |
| Divisions: | |
| Journal or Publication Title: | Natural Product Research |
| Journal Index: | Scopus |
| Identification Number: | https://doi.org/10.1080/14786419.2019.1682576 |
| ISSN: | 14786419 (ISSN) |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.bmsu.ac.ir/id/eprint/571 |
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