Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

EFFECT OF THERAPEUTIC ULTRASOUND ON FOLLICULOGENESIS, ANGIOGENESIS AND APOPTOSIS AFTER HETEROTOPIC MOUSE OVARIAN TRANSPLANTATION

(2014) EFFECT OF THERAPEUTIC ULTRASOUND ON FOLLICULOGENESIS, ANGIOGENESIS AND APOPTOSIS AFTER HETEROTOPIC MOUSE OVARIAN TRANSPLANTATION. Ultrasound in Medicine and Biology. pp. 1535-1544. ISSN 0301-5629

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Effect of therapeutic ultrasound on folliculogenesis, angiogenesis and apoptosis after heterotopic mouse ovarian transplantation.pdf

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Abstract

One of the challenges in ovarian transplantation is ischemia-reperfusion damage. When transitional tissue faces an acute and critical condition in terms of blood supply (immediately after organ transplantation), treatment with low-intensity pulsed ultrasound (LIPUS) seems to be very beneficial. The aim of this study was to evaluate the effects of ultrasound therapy on heterotopic transplanted mouse ovarian tissue. Adult female Naval Medical Research Institute mice were divided into three groups. In the experimental groups, the transplanted ovary was exposed 5 min daily to ultrasound with an intensity of 0.3 W/cm(2), frequency of 3 MHz and pulse mode of 1: 4. The grafted ovaries were assessed with the usual histology and immunohistochemistry techniques. Results indicate that more CD31 angiogenic factor was expressed in irradiated animals than in control animals, and ultrasound therapy resulted in better follicular preservation, especially after 14 d. In conclusion, therapeutic ultrasound may accelerate and increase re-angiogenesis and can help to promote ovarian follicular growth. (E-mail: eimanih@royaninstitute.org) (c) 2014 World Federation for Ultrasound in Medicine & Biology.

Item Type: Article
Keywords: Angiogenesis Low-intensity pulsed ultrasound waves Mouse Ovarian transplantation intensity pulsed ultrasound gene-expression in-vivo follicles oocytes fertilization autografts muscle fresh Acoustics Radiology, Nuclear Medicine & Medical Imaging
Divisions:
Page Range: pp. 1535-1544
Journal or Publication Title: Ultrasound in Medicine and Biology
Journal Index: ISI
Volume: 40
Number: 7
Identification Number: https://doi.org/10.1016/j.ultrasmedbio.2014.02.006
ISSN: 0301-5629
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/5775

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