Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Protective effect of ivy leaf extract on paracetamol-induced oxidative stress and nephrotoxicity in mice

(2019) Protective effect of ivy leaf extract on paracetamol-induced oxidative stress and nephrotoxicity in mice. Journal of HerbMed Pharmacology. pp. 64-68. ISSN 23455004 (ISSN)

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Abstract

Introduction: The aim of the study was to evaluate the protective effect of Hedera helix (ivy) leaf extract on paracetamol-induced oxidative stress and renal toxicity in mouse model. Methods: Sixty male Swiss albino mice were randomly divided into six equal groups. Group A: as the control group, received NaCl 0.9. Group B: received a single (i.p.) injection of paracetamol (600 mg/kg). Pretreatment groups: included T1 (50 mg/kg), T2 (100 mg/kg), T3 (200 mg/kg), and T4 (300 mg/kg) which were treated with ivy leaf extract in different doses. The mice were sacrificed under mild anesthesia and the blood samples were collected to titrate the levels of serum blood urea nitrogen (BUN), creatinine and, uric acid. Kidneys were removed for histopathological examination. Results: Paracetamol administration significantly increased the BUN, creatinine and uric acid levels (P < 0.05). Treatment with Ivy leaf extract resulted in a significant reduction in serum creatinine, uric acid and BUN concentrations in comparison with the paracetamol group. Ivy leaf extract treatment similarly reduced histological alteration induced by paracetamol. Conclusion: This study can be used as prove of reading that ivy leaf extract might be used to prevent renal damage induced by paracetamol. © 2019 Nickan Research Institute. All Right Reserved.

Item Type: Article
Keywords: Ivy leaf extract Kidney Medicinal plant Oidative stress Protective effect paracetamol plant extract urea animal experiment animal model animal tissue Article cell infiltration comparative study edema histopathology ivy kidney injury male mouse necrosis nephrotoxicity nonhuman oxidative stress urea nitrogen blood level uric acid blood level
Divisions:
Page Range: pp. 64-68
Journal or Publication Title: Journal of HerbMed Pharmacology
Journal Index: Scopus
Volume: 8
Number: 1
Identification Number: https://doi.org/10.15171/jhp.2019.11
ISSN: 23455004 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/583

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