Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

The effect of eight weeks endurance training and high-fat diet on appetite-regulating hormones in rat plasma

(2014) The effect of eight weeks endurance training and high-fat diet on appetite-regulating hormones in rat plasma. Iranian Journal of Basic Medical Sciences. pp. 237-243. ISSN 2008-3866

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Abstract

Objective(s): Consumption of high-fat foods is one of the major causes of obesity. Physical exercise is a strategy used to counteract obesity. The aim of this study was to investigate the effect of eight weeks endurance training and high-fat diet (HFD) on appetite-regulating hormones in rat plasma. Materials and Methods: Twenty eight male Wistar rats were randomly divided into four groups: Control group with standard diet (CSD), endurance training with a standard diet (ESD), control group with high-fat diet (CHFD) and endurance training with high-fat diet (EHFD). Twenty-four hr after the last training session, the blood samples were obtained and analyzed for hormones levels. Results: The significant increased weight gain and food intake and decreased plasma nesfatin-1 and PYY3-36 levels were observed in CHFD group, while exercise under the HFD antagonized these effects. There were no significant changes in ghrelin, insulin and leptin levels in different groups. Conclusion: These results suggest that exercise can prevent fattening effect of HFD. Probably, performing exercise makes a reduction of food intake and weight gain in rat via the increase in nesfatin-1 and PYY levels. However, further studies are necessary to understand the exact mechanisms involved in this field.

Item Type: Article
Keywords: Endurance training Food intake High fat diet Peptide hormones high-intensity exercise acylated ghrelin energy-intake aerobic exercise resistance exercise salivary cortisol food-intake peptide yy responses men Research & Experimental Medicine Pharmacology & Pharmacy
Divisions:
Page Range: pp. 237-243
Journal or Publication Title: Iranian Journal of Basic Medical Sciences
Journal Index: ISI
Volume: 17
Number: 4
ISSN: 2008-3866
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/5837

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