Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Polyphenols: Well Beyond The Antioxidant Capacity: Gallic Acid and Related Compounds as Neuroprotective Agents: You are What You Eat!

(2014) Polyphenols: Well Beyond The Antioxidant Capacity: Gallic Acid and Related Compounds as Neuroprotective Agents: You are What You Eat! Current Pharmaceutical Biotechnology. pp. 362-372. ISSN 1389-2010

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Abstract

Gallic acid (3,4,5-trihydroxybenzoic acid) is a phenolic acid widely distributed in many different families of higher plants, both in free state, and as a part of more complex molecules, such as ester derivatives or polymers. In nature, gallic acid and its derivatives are present in nearly every part of the plant, such as bark, wood, leaf, fruit, root and seed. They are present in different concentrations in common foodstuffs such as blueberry, blackberry, strawberry, plums, grapes, mango, cashew nut, hazelnut, walnut, tea, wine and so on. After consumption, about 70 of gallic acid is adsorbed and then excreted in the urine as 4-O-methylgallic acid. Differently, the ester derivatives of gallic acid, such as catechin gallate ester or gallotannins, are hydrolyzed to gallic acid before being metabolized to methylated derivatives. Gallic acid is a well known antioxidant compounds which has neuroprotective actions in different models of neurodegeneration, neurotoxicity and oxidative stress. In this review, we discuss about the neuroprotective actions of gallic acid and derivatives and their potential mechanisms of action.

Item Type: Article
Keywords: Gallic acid neuroprotective activity polyphenos protective activity induced oxidative stress tea epigallocatechin-3-gallate egcg amyloid precursor protein grape seed extract green tea alzheimers-disease inflammatory mechanisms microglial activation parkinsons-disease multiple-sclerosis Biochemistry & Molecular Biology Pharmacology & Pharmacy
Divisions:
Page Range: pp. 362-372
Journal or Publication Title: Current Pharmaceutical Biotechnology
Journal Index: ISI
Volume: 15
Number: 4
Identification Number: https://doi.org/10.2174/138920101504140825120737
ISSN: 1389-2010
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/5891

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