Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Prevalence of Occult Hepatitis B Virus in Plasma and Peripheral Blood Mononuclear Cell Compartments of Patients With Chronic Hepatitis C Infection in Tehran-Iran

(2013) Prevalence of Occult Hepatitis B Virus in Plasma and Peripheral Blood Mononuclear Cell Compartments of Patients With Chronic Hepatitis C Infection in Tehran-Iran. Hepatitis Monthly. p. 7. ISSN 1735-143X

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Abstract

Background: Occult hepatitis B virus (HBV) infection (OBI) is frequently reported in patients with chronic hepatitis C virus (HCV) infection. An association between OBI and more liver damage, cirrhosis, hepatocellular carcinoma, and reduced response to interferon therapy in patients with HCV infection is suggested. Objectives: The aim of this study was to determine the prevalence of occult HBV, and evaluate its clinical influence on patients with chronic HCV. Patients and Methods: A cohort study including50 patients with positive results for HCV, and negative results for HBsAg tests was performed. The patients were divided into two groups: one group had positive results for both HCV and occult HBV tests (n = 18), and the other had positive results for HCV, but negative findings for occult HBV (n = 32). All were treated with PEG-IFN alpha-2a and Ribavirin. Presence of HCV RNA was followed in these patients. Results: HBV-DNA was detected using nested-PCR in 20 of plasma and 32.6 of peripheral blood mononuclear cell (PBMC) compartments. No significant differences were observed between patients with and without occult HBV for sex, age, duration of HCV infection, histological markers, presence of anti-HBc, HCV viral load, and HCV genotype. The response rate was significantly higher in patients with positive results for HBV-DNA test compared to those with negative findings (100 vs. 71.9 , P & lt; 0.05). Conclusions: In conclusion, occult HBV was found in 36 of patients with negative results for HBsAg, but positive results for HCV. Detection of HBV-DNA in both PBMCs and plasma together in comparison with plasma alone provided more true identification of OBI. The SVR rate was significantly higher in coinfected patients than mono-infected ones.

Item Type: Article
Keywords: Hepatitis B Hepatitis C Virus Peripheral Blood Mononuclear Cell hepatocellular-carcinoma pegylated interferon hbv infection coinfection impact hcv dna diagnosis ribavirin therapy Gastroenterology & Hepatology
Divisions:
Page Range: p. 7
Journal or Publication Title: Hepatitis Monthly
Journal Index: ISI
Volume: 13
Number: 5
Identification Number: https://doi.org/10.5812/hepatmon.10134
ISSN: 1735-143X
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/6048

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