Abstract

Stress can disrupt the physiological homeostasis of biological organisms which follow by behavioral impairment; especially it can induce deficits in learning and memory process. Studies showed that Cinnamaldehyde (CA) have many pharmacological activities such as anti-diabetic, antioxidant, cognitive enhancer, anti-inflammatory and anti-cancer activity. To examine the effects of Cinnamaldehyde on stress-induced cognitive deficits, we assessed and compared the Electric foot Shock Stress (EShS) and Immobility stress (ImmS) on Barnes maze acquisition. In this experiment 60 Male Wistar rats were randomly divided into 5 groups (n=12): vehicle, two groups with stress and two groups with stress plus CA treatment. The learning and memory process were measured by Barnes maze. One week stress induction was begun two days before starting acquisition protocol and during it. Cinnamaldehyde was administered orally via gavage (20mg/kg/day) during experiment. This study demonstrated that both EShS and ImmS could disrupt the acquisition and memory with Barnes maze. The time of latency and distance pursuit to find goal box and number of errors increased in stress induced groups. Treatment with Cinnamaldehyde improves learning and memory process both in control and stress induced groups. Furthermore, the improvement effect of Cinnamaldehyde was better in electric foot shock stressed group than restraint group. The present study suggest that Cinnamaldehyde can improve learning and memory process both in control and stress-induced groups.The improvement against electric foot shock stress is better than immobilization. © 2019, SILAE (Italo-Latin American Society of Ethnomedicine). All rights reserved.