Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Investigation of the Effects of Chlorella Vulgaris Supplementation in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial

(2012) Investigation of the Effects of Chlorella Vulgaris Supplementation in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial. Hepato-Gastroenterology. pp. 2099-2103. ISSN 0172-6390

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Investigation of the effects of Chlorella vulgaris as an adjunctive therapy for dyslipidemia Results of a randomised open-label clinical trial.pdf

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Abstract

Background/Aims: To investigate the advantage of Chlorella vulgaris supplementation as an adjunctive therapy in patients with non-alcoholic fatty liver disease (NAFLD). Methodology: In a randomized, open-label clinical trial, 76 individuals with NAFLD were randomly assigned to: 1) Chlorella group (n=33), receiving C. vulgaris extract (1200mg/day) + metformin (750mg/day) + vitamin E (200mg/day) for 3 months, or 2) Metformin group (n=43), receiving metformin (1250mg/day) + vitamin E (200mg/day) for 3 months. Weight, body mass index (BMI), homeostasis model assessment of insulin resistance (HOMA-IR) index as well as serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), insulin, total and direct bilirubin, fasting blood sugar (FBS), glycated hemoglobin (HbA(1c)), uric acid, albumin and lipid profile were evaluated at baseline and at the end of trial. Results: Weight and BMI were decreased in both groups. Serum ALT, AST, triglycerides, uric acid, HbA(1c) and HOMA-IR index were reduced only in the Chlorella group whereas significant changes in total cholesterol, LDL, HDL and FBS were only observed in the metformin group. There were also borderline significant reductions in insulin and FBS in the Chlorella group. Conclusions: The findings of the present trial indicated that addition of C. vulgaris extract to the therapeutic regimen of NAFLD including metformin and vitamin E, is associated with favorable effects on serum levels of transaminases, triglycerides as well as insulin sensitivity Therefore, C. vulgaris extract might be a promising hepatoprotective supplement for patients with NAFLD.

Item Type: Article
Keywords: Chlorella vulgaris Non-alcoholic fatty liver disease Insulin resistance Hepatic injury Transaminase Lipid profile serum uric-acid placebo-controlled trial metabolic syndrome insulin-resistance triglyceride levels diabetes-mellitus oxidative stress association rats steatohepatitis Gastroenterology & Hepatology Surgery
Divisions:
Page Range: pp. 2099-2103
Journal or Publication Title: Hepato-Gastroenterology
Journal Index: ISI
Volume: 59
Number: 119
Identification Number: https://doi.org/10.5754/hge10860
ISSN: 0172-6390
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/6199

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