Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Cochlear implantation outcomes in children with Waardenburg syndrome

(2012) Cochlear implantation outcomes in children with Waardenburg syndrome. European Archives of Oto-Rhino-Laryngology. pp. 2179-2183. ISSN 0937-4477

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Waardenburg syndrome (WS) is an autosomal dominant disease, characterized by dystopia canthorum, hyperplasia of the eyebrows, heterochromia iridis, white forelock, and congenital sensori-neural hearing loss (SNHL). The aim of this study was to evaluate the outcome of cochlear implantation in children with WS and compare it with children with pure SNHL. In a prospective study we evaluated 336 cochlear implanted children from 2008 to 2010. The WS was diagnosed by its established criteria and for control group children without any dysmorphic features, anatomical, behavioral, and developmental disorders were also enrolled. We evaluated children of both groups 1 year after cochlear implantation by categories of auditory performance (CAP) and speech intelligibility rating (SIR) tests. Eighty-one children out of the total 336 who had SNHL were included in study. Out of these 75 (22.3) were healthy and six (1.78) had WS. Of the 75 healthy children 40 (53.3) were girls, while of the six children with WS, three (50) were girls. There was a significant difference in SIR between WS and cases with pure SNHL (2.67 +/- A 1.03 vs. 3.79 +/- A 1.11, p = 021) however, the difference was not significant in CAP (4 +/- A 1.26 vs. 5.13 +/- A 1.13, p = 0.082). Prevalence of WS was 1.78 at Baqiyatallah Cochlear Implant Center. One year after implantation there was no significant difference in auditory outcome; however, the difference in speech outcome was significant between WS and cases with pure SNHL.

Item Type: Article
Keywords: Waardenburg syndrome Sensori-neural hearing loss Auditory and speech outcome Cochlear implantation speech-perception hearing-loss language intelligibility communication skills age Otorhinolaryngology
Page Range: pp. 2179-2183
Journal or Publication Title: European Archives of Oto-Rhino-Laryngology
Journal Index: ISI
Volume: 269
Number: 10
Identification Number:
ISSN: 0937-4477
Depositing User: مهندس مهدی شریفی

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