Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Effect of prenatal immobilization stress on spatial memory, anxiety-like behavior and brain BDNF concentration in the F1 generation male mice

(2018) Effect of prenatal immobilization stress on spatial memory, anxiety-like behavior and brain BDNF concentration in the F1 generation male mice. Scientific Journal of Kurdistan University of Medical Sciences. pp. 73-84. ISSN 1560652X (ISSN)

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Abstract

Background and Aim: In this study, we investigated the effect of immobilization stress during pregnancy on the spatial memory, anxiety-like behavior and brain BDNF level in F1 generation male NMRI mice. Materials and Methods: Twenty female pregnant mice were randomly divided into stress and control groups. The stress group received stress using a restraint cylinder (6 cm ID, 20 cm L) 60 min/day from the 1st to the 15th day of pregnancy. The control group did not receive stress. The male F1 offspring was nursed by their mothers (n=10/group) until reaching weights between 20 and 25 g. Then they were tested for spatial memory using Barnes maze and anxiety-like behavior by the elevated plus-maze. Also, brain BDNF level was measured by means of an ELISA reader. Results: Barnes maze test results showed that the time and distance to reach the target hole were significantly (p<0. 001) increased in the stress group. Also, the number of errors and anxiety-like behavior in the stress group were significantly (p<0. 001) increased compared to those in the control group (p<0. 001). BDNF level in the brain was significantly (p<0. 05) higher in the control group. Conclusion: The present study indicated that prenatal stress can lead to decreased level of BDNF in the brain of the offspring which may result in spatial memory disorder and anxiety-like behavior. © 2018, Kurdistan University of Medical Sciences. All rights reserved.

Item Type: Article
Keywords: Anxiety-like behavior Barnes maze BDNF Restraint stress Spatial memory
Divisions:
Page Range: pp. 73-84
Journal or Publication Title: Scientific Journal of Kurdistan University of Medical Sciences
Journal Index: Scopus
Volume: 23
Number: 3
ISSN: 1560652X (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/623

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