Abstract

The objective of the present study was to assess effect of Artemisia dracunculus in combination with chitosan nanoparticle biofilm on MRSA infected excisional wounds. Thirty rats were randomized into five groups of six rats each. Group I: Animals with uninfected wounds treated with 0.9 saline solution. Group II: Animals with infected wounds treated with saline. Group III: Animals with infected wounds were dressed with chitosan nanoparticle biofilm. Group IV: Animals with infected wounds were treated topically with Artemisia dracunculus and Group V: Animals with infected wounds were treated topically with Artemisia dracunculus and dressed with chitosan nanoparticle biofilm. Wound size was measured on 6, 9, 12, 15, 18 and 21days after surgery. Microbiology, reduction in wound area and hydroxyproline contents indicated that there was significant difference (P < 0.05) between group V and other groups. Quantitative histological studies and mean rank of the qualitative studies demonstrated that there was significant difference (P < 0.05) between group V and other groups. It was concluded that the Artemisia dracunculus with chitosan nanoparticle biofilm had a reproducible wound healing potential and hereby justified its use in practice. © 2018 Ranjbar and Yousefi.