Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

A Plausible Anti-Apoptotic Role of Up-Regulated OCT4B1 in Bladder Tumors

(2012) A Plausible Anti-Apoptotic Role of Up-Regulated OCT4B1 in Bladder Tumors. Urology Journal. pp. 574-580. ISSN 1735-1308

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Purpose: To investigate and compare the expression of OCT4B1 between tumor and non-tumor bladder tissues. Materials and Methods: We investigated the expression of OCT4B1 in 30 tumor and non-tumor surgical specimens of the bladder, using the TaqMan real-time polymerase chain reaction approach and by carefully designing primers and probes specific for the amplificaion of the variant. Results: Most tumor and non-tumor samples of the bladder showed OCT4B1 expression, but its expression level was significantly higher in the tumors (P < .002). Moreover, the up-regulation of OCT4B1 was more significant in high-grade tumors compared to the low-grade ones (P < .05). We have also employed the RNA interference strategy to evaluate the functional role of OCT4B1 in a bladder cancer cell line, 5637. Suppression of OCT4B1 caused some changes in cell cycle distribution, and significantly elevated the rate of apoptosis in the cells. Conclusion: Our findings suggest that OCT4B1 plays a potential role in tumor initiation and/or progression of the bladder cancer. Additionally, OCT4B1 can be regarded as a new tumor marker for detection, classification, and treatment of the bladder cancer. However, more experimental studies are needed to replicate our findings.

Item Type: Article
Keywords: cancer stem cells urinary bladder neoplasms apoptosis neoplasm invasiveness prognosis pluripotent stem-cells transcription factor mammalian embryo cancer expression carcinogenesis biology tissues marker oct-4 Urology & Nephrology
Page Range: pp. 574-580
Journal or Publication Title: Urology Journal
Journal Index: ISI
Volume: 9
Number: 3
ISSN: 1735-1308
Depositing User: مهندس مهدی شریفی

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