Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

The effect of saffron aqueous extract and crocin on PTSD rat models: The focus on learning and spatial memory

(2018) The effect of saffron aqueous extract and crocin on PTSD rat models: The focus on learning and spatial memory. Journal of Zanjan University of Medical Sciences and Health Services. pp. 34-42. ISSN 16069366 (ISSN)

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Abstract

Background & Objective: Post traumatic stress disorder (PTSD) is an anxiety reaction, which occurs as a result of encountering a seriously traumatic event during one’s lifetime. The aim of this study was to evaluate the effect of saffron aqueous extract and crocin on spatial memory and learning with the Barnes maze in a PTSD model on male Wistar rats (Weighting 200–250 gr). Materials & Methods: Wistar rats (n=48) were randomly divided into two groups: PTSD and non-PTSD. The PTSD group first received intra-cerebero-ventricular (ICV) administration of 10 µg/rat aqueous saffron extract, crocin or saline and then an electric foot shock. After 21 days, both groups were returned to the electric shock box in order to remember stressors without receiving any shocks. Corticosterone levels were then measured in the samples. Concurrently, a digital camera was recording the animals’ behaviors. Upon this, spatial learning and memory was assessed for five consecutive days. Results: The saffron extract and crocin caused a significant increase (P<0.001) in corticosterone levels and a significant reduction (P<0.05) in freezing behavior, as well as a significant difference (P<0.001) in spatial learning of the two groups. Conclusion: Our results indicated the potential role of saffron aqueous extract and its active derivative (crocin) in improving behavioral symptoms and spatial learning in PTSD models. © 2019, Zanjan University of Medical Sciences and Health Services. All rights reserved.

Item Type: Article
Keywords: Corticosterone Crocin Spatial learning Spatial memory Traumatic stress disorder Crocus sativus extract adult animal experiment animal model animal tissue Article Barnes maze test behavior cognitive function test controlled study corticosterone blood level Crocus sativus drug effect electric shock enzyme linked immunosorbent assay footshock freezing latent period male nonhuman posttraumatic stress disorder rat stigma total distance traveled
Divisions:
Page Range: pp. 34-42
Journal or Publication Title: Journal of Zanjan University of Medical Sciences and Health Services
Journal Index: Scopus
Volume: 26
Number: 119
Identification Number: https://doi.org/10.352/jambr.26.119.34
ISSN: 16069366 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/631

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