Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Influence of ramiprilat and losartan on ischemia reperfusion injury in rat hearts

(2012) Influence of ramiprilat and losartan on ischemia reperfusion injury in rat hearts. Journal of the Renin-Angiotensin-Aldosterone System. pp. 29-35. ISSN 1470-3203

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Abstract

Hypothesis/introduction: Our aim was to investigate whether a non-hypotensive dose of ramiprilat and losartan has myocardial protective effects during myocardial ischemia/reperfusion in vivo. Materials and methods: Three groups of rats were given 10 mg/kg per day of losartan for one (L-1W), four (L-4W) or 10 (L-10W) weeks. Another three groups were given 50 A mu g/kg per day of ramiprilat for one (R-1W), four (R-4W) or 10 (R-10W) weeks. The animals underwent 30 min of left anterior descending artery occlusion and subsequent reperfusion for 120 min. Results: Myocardial infarct size (IS) was reduced in R-1W (28.4 +/- 6.3, p < 0.001), R-4W (27.8 +/- 7.4, p < 0.001), L-4W (31.8 +/- 6, p < 0.05) and L-10W (25.3 +/- 5.7, p < 0.001) groups compared with a saline group (48.3 +/- 7.8). A significant reduction in the number of ventricular ectopic beats (VEBs) was noted in groups R-1W (209 +/- 41, p < 0.01), R-4W (176 +/- 39, p < 0.01), L-4W (215 +/- 52, p < 0.05) and L-10W (191 +/- 61, p < 0.01 vs. saline 329 +/- 48). The incidence of irreversible ventricular fibrillation (VF) and mortality were decreased significantly only in L-10W group. There were no significant decreases in episodes of VT, the incidence of irreversible VF and mortality in all of the groups treated with ramiprilat. Conclusion: These data indicate that losartan and ramiprilat protect the heart against ischemia/reperfusion injury independently of their hemodynamic effects but in a time-dependent manner.

Item Type: Article
Keywords: Arrhythmia infarct size losartan ramiprilat myocardial infarct size angiotensin receptor blockers converting enzyme-inhibitors high-risk patients ace-inhibitors endothelial function nitric-oxide captopril therapy failure Cardiovascular System & Cardiology
Divisions:
Page Range: pp. 29-35
Journal or Publication Title: Journal of the Renin-Angiotensin-Aldosterone System
Journal Index: ISI
Volume: 13
Number: 1
Identification Number: https://doi.org/10.1177/1470320311426025
ISSN: 1470-3203
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/6364

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