Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Clinical Features and Seroepidemiology of Anti-HDV Antibody in Patients With Chronic Hepatitis B Virus Infection in Iran: A Meta-Analysis

(2011) Clinical Features and Seroepidemiology of Anti-HDV Antibody in Patients With Chronic Hepatitis B Virus Infection in Iran: A Meta-Analysis. Hepatitis Monthly. pp. 960-967. ISSN 1735-143X

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Abstract

Context: Hepatitis delta virus (HDV) leads to the most severe form of chronic viral hepatitis. Objectives: To determine the prevalence of HDV and create pooled estimations of possible risk factors, a systematic review was conducted to collect all epidemiological studies on HDV among chronic hepatitis B patients in Iran. Data Sources: In this systematic review, databases such as PubMed, Embase, ISI, Google scholar, and Iranian databases (Maglran, lranmedex, and SID) were searched. Study Selection: Studies that clearly stated information about the number of HBsAg positive patients infected with HDV were selected. Data Extraction: The name of the city, the author's name, year of study, HDV detection method, sample size, HBsAg positive frequency, mean age, total prevalence of HDV, and risk factors were extracted. Results: The pooled HDV prevalence was 7.8 (95 CI:5.89 - 9.71). In the survey-data analysis, HDV prevalence was 6.61. HDV prevalence was 30.47 (95 CI: 9.76 to 51.19), 14.4 (95 CI: 7.72 to 21.07), and 4.94 (95 CI: 3.73 to 6.15) in cirrhotic, chronic-hepatitis, and inactive-carrier patients, respectively. Pooled ORs were calculated for several factors common to Iranian HBsAg-positive patients, including history of blood transfusion OR: 1.1 (95% CI: 0.40 to 2.98), intravenous drug abuse OR: 1.6 (95% CI: 0.78 to 3.21), previous hemodialysis OR: 1.72 (95% Cl: 0.79 to 3.76), and HBeAg-positive status OR:1.26 (95% CI: 0.66 to 2.4). Conclusions: The prevalence of HDV is less common in Iran than in endemic regions such as Italy and Turkey; however, it is a severe form of hepatitis in HBsAg-positive patients. The most probable route of HDV transmission is hematologic, which suggests the importance of blood screening for HDV, especially in groups with numerous blood transfusions. Copyright (C) 2011 Kowsar M. P. Co. All rights reserved.

Item Type: Article
Keywords: Hepatitis D Review Meta-Analysis Iran Prevalence Epidemiology hbsag positive patients delta-virus phylogenetic analysis prevalence epidemiology impact cirrhosis province seroprevalence tehran Gastroenterology & Hepatology
Divisions:
Page Range: pp. 960-967
Journal or Publication Title: Hepatitis Monthly
Journal Index: ISI
Volume: 11
Number: 12
Identification Number: https://doi.org/10.5812/kowsar.1735143X.805
ISSN: 1735-143X
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/6446

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