Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Effect of cesarean section on the risk of perinatal transmission of hepatitis C virus from HCV-RNA+/HIV- mothers: a meta-analysis

(2011) Effect of cesarean section on the risk of perinatal transmission of hepatitis C virus from HCV-RNA+/HIV- mothers: a meta-analysis. Archives of Gynecology and Obstetrics. pp. 255-260. ISSN 0932-0067

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Abstract

Hepatitis C virus (HCV) vertical transmission is considered the main route of HCV infection in children. Some authors have stated that cesarean section (C/S) can reduce perinatal HCV transmission. However, the study findings are heterogeneous and high-quality studies are lacking. To evaluate the effect of mode of delivery on the risk of perinatal mother-to-infant transmission of HCV. Only the peer-reviewed published studies that compared perinatal transmission rate of HCV in elective or emergency cesarean section with vaginal delivery in HCV-RNA+/HIV- mothers were included. We applied the random effect model of DerSimonian and Laird method with heterogeneity and sensitivity analyses. We identified 8 studies that involved 641 unique mother-infant pairs which fulfilled our inclusion criteria. Aggregation of study results did not show a significant decrease in HCV vertical transmission among study (mothers who underwent C/S) versus control (mothers who gave birth vaginally) patients pooled odds ratio, 1.1 (95% CI 0.45-2.67). The P value was 0.35 for our test of heterogeneity. Our meta-analysis suggests that C/S does not decrease perinatal HCV transmission from HCV-RNA+/HIV- mothers to infants.

Item Type: Article
Keywords: Meta-analysis HCV Cesarean section Vaginal delivery Vertical transmission to-child transmission vertical transmission infant transmission pregnant-women infection reevaluation delivery cohort bias load Obstetrics & Gynecology
Divisions:
Page Range: pp. 255-260
Journal or Publication Title: Archives of Gynecology and Obstetrics
Journal Index: ISI
Volume: 283
Number: 2
Identification Number: https://doi.org/10.1007/s00404-010-1588-9
ISSN: 0932-0067
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/6603

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