Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Potential efficacy of ginger as a natural supplement for nonalcoholic fatty liver disease

(2011) Potential efficacy of ginger as a natural supplement for nonalcoholic fatty liver disease. World Journal of Gastroenterology. pp. 271-272. ISSN 1007-9327

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Abstract

Nonalcoholic fatty liver disease (NAFLD) is one of the most common liver diseases and its prevalence is likely to reach epidemic proportions. According to the "two-stage hypothesis" proposed for the pathophysiology of NAFLD, insulin resistance, oxidative stress and pro-inflammatory cytokines are among the key promoters of the disease. Here, ginger has been hypothesized to prevent NAFLD or blunt its progression via several mechanisms, such as sensitizing insulin effects, activating peroxisome proliferator-activated receptor gamma which induces adiponectin and down-regulates pro-inflammatory cytokines, changing the balance between adiponectin and tumor necrosis factor-alpha in favor of adiponectin, promoting considerable antioxidant effects and antidyslipidemic properties, and reducing hepatic triglyceride content which can prevent steatosis. The aforementioned mechanisms imply that ginger possesses interesting potentials for serving as a natural supplement for the prevention and treatment of NAFLD. Therefore, conducting trials to explore its benefits in clinical practice is greatly recommended. (C) 2011 Baishideng. All rights reserved.

Item Type: Article
Keywords: Nonalcoholic fatty liver disease Ginger Insulin resistance Oxidative stress Inflammation zingiber-officinale alpha adiponectin 6-gingerol expression Gastroenterology & Hepatology
Divisions:
Page Range: pp. 271-272
Journal or Publication Title: World Journal of Gastroenterology
Journal Index: ISI
Volume: 17
Number: 2
Identification Number: https://doi.org/10.3748/wjg.v17.i2.271
ISSN: 1007-9327
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/6610

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