Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Oxidative Stress Status in Renal Transplant Recipients

(2010) Oxidative Stress Status in Renal Transplant Recipients. Experimental and Clinical Transplantation. pp. 38-44. ISSN 1304-0855

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Abstract

Objectives: Despite the demonstration of oxidative stress in patients with end-stage renal disease, the oxidative status during and after a renal transplant are not completely understood. Hepatocyte growth factor is reported to act as an endogenous factor against oxidative stress. The aim of this study was to evaluate the pattern of changes in plasma oxidative status and hepatocyte growth factor levels in living-donor renal transplant recipients during the early phase after transplant. Materials and Methods: Nineteen patients who underwent a renal transplant were included. All were on cyclosporine-based immunosuppression. Plasma levels of malondialdehyde, ferric reducing activity, hepatocyte growth factor, vitamin E, erythrocyte glutathione, and superoxide dismutase activities were determined before, and on the second, seventh, and 12(th) days after the transplant. Results: High malondialdehyde concentration and low superoxide dismutase activity were seen before and 48 hours after transplant compared with healthy subjects. Significant reductions in plasma ferric reducing activity, malondialdehyde, and hepatocyte growth factor were seen on the seventh and twelfth days after transplant, compared with the before-transplant data. Direct correlations were found between hepatocyte growth factor levels and ferric reducing activity of plasma as well as hepatocyte growth factor and creatinine or uric acid. Conclusions: Renal transplant recipients display persistent oxidative stress during the early phase of transplant. The pattern of oxidative changes should be considered for appropriate time, dosage, type, and the duration of antioxidant therapy in these patients.

Item Type: Article
Keywords: Kidney Reactive oxygen species Hepatocyte growth factor Living-donor hepatocyte growth-factor total antioxidant capacity lipid-peroxidation glutathione-peroxidase superoxide-dismutase chronic rejection alpha-tocopherol cyclosporine-a graft function vitamin-e Transplantation
Divisions:
Page Range: pp. 38-44
Journal or Publication Title: Experimental and Clinical Transplantation
Journal Index: ISI
Volume: 8
Number: 1
ISSN: 1304-0855
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/6756

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