(2010) Interaction of sulfur mustard with rat liver salt fractionated chromatin. International Journal of Biological Macromolecules. pp. 104-108. ISSN 0141-8130
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Abstract
In this study, the interaction of an alkylating agent, sulfur mustard (SM) with rat liver active (S(1) and S(2)) and inactive (P(2)) chromatin was investigated employing UV/vis spectroscopy and gel electrophoreses. The results show that SM affects the chromatin structure in a dose-dependent manner. The binding of SM to fractions is different. At lower concentrations (<500 mu M), SM seems to unfold the structure and at higher concentrations, it induces aggregation and condensation of chromatin possibly via forming cross-links between the chromatin components. The extent of condensation in S(2) is higher when compared to the P(2) fraction. (C) 2009 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Keywords: | Sulfur mustard Active and inactive chromatin Rat liver transcriptionally active chromatin yoshida ascites sarcoma dna cross-linking nuclear proteins endothelial-cells chemical warfare apoptosis keratinocytes chlorambucil agents Biochemistry & Molecular Biology Chemistry Polymer Science |
| Divisions: | |
| Page Range: | pp. 104-108 |
| Journal or Publication Title: | International Journal of Biological Macromolecules |
| Journal Index: | ISI |
| Volume: | 46 |
| Number: | 1 |
| Identification Number: | https://doi.org/10.1016/j.ijbiomac.2009.10.006 |
| ISSN: | 0141-8130 |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.bmsu.ac.ir/id/eprint/6777 |
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