Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Pre-transplant and post-transplant soluble CD30 for prediction and diagnosis of acute kidney allograft rejection

(2009) Pre-transplant and post-transplant soluble CD30 for prediction and diagnosis of acute kidney allograft rejection. International Urology and Nephrology. pp. 687-693. ISSN 0301-1623

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Abstract

Serum levels of soluble CD30 (sCD30) have been considered as a predictor of acute kidney allograft rejection. We have evaluated the pre-transplant and post-transplant levels of sCD30 with the aim of determining its value in predicting and diagnosing kidney rejection. We measured sCD30 serum levels before kidney transplantation, 5 days post-operatively, and at creatinine elevation episodes. The predictive value of sCD30 for diagnosing acute rejection (AR) within the first 6 post-operative months was assessed in 203 kidney recipients from living donors. Pre-transplant and post-operative levels of serum sCD30 were 58.10 +/- A 52.55 and 51.55 +/- A 49.65 U/ml, respectively (P = 0.12). Twenty-three patients experienced biopsy-proven acute rejection, and 28 had acute allograft dysfunction due to non-immunologic diseases. The pre-transplant sCD30 level was not different between patients with and without AR. However, post-transplant sCD30 was higher in the AR group. The median serum level of post-transplant sCD30 was 52 U/ml in the AR group and 26.3 U/ml in a control group (P < 0.001). The relative changes of sCD30 on day 5 were higher in patients with AR (P = 0.003). Based on post-transplant sCD30 levels, we were able to differentiate between kidney recipients who experienced an AR within 6 months post-surgery and those without an AR (cutoff value 41 U/ml; sensitivity 70; specificity 71.7). The level of sCD30 during periods of elevated serum creatinine was not independently associated with the diagnosis of AR. Post-transplant sCD30 levels and their relative changes are higher in patients experiencing AR. We propose further studies on the post-transplant trend of this marker for the prediction of AR.

Item Type: Article
Keywords: Acute rejection Diagnosis Graft survival Kidney transplantation Soluble CD30 transplant recipients identification interleukin-10 scd30 risk Urology & Nephrology
Divisions:
Page Range: pp. 687-693
Journal or Publication Title: International Urology and Nephrology
Journal Index: ISI
Volume: 41
Number: 3
Identification Number: https://doi.org/10.1007/s11255-008-9505-x
ISSN: 0301-1623
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/6854

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