Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Phylogenetic Analysis of Twenty-Six Cases of Hepatitis Delta Virus Isolates in Tehran, Iran

(2009) Phylogenetic Analysis of Twenty-Six Cases of Hepatitis Delta Virus Isolates in Tehran, Iran. Hepatitis Monthly. pp. 196-200. ISSN 1735-143X

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Abstract

Background and Aims: Hepatitis delta virus (HDV) is an RNA virus that can lead to severe acute, and chronic forms of liver disease using the helper function of the hepatitis B virus. HDV strains are categorized into three genotypes and eight clades, which distribute geographically. The prevalence rate of HDV infection varies from 2.4 to 10 percent in blood donors for chronic liver disease in Iran. The aim was to find out the phylogenetic background of samples isolated in Tehran. Methods: A molecular phylogenetic analysis in some samples has been conducted in Iran previously. However, the number of cases did not cover the whole country. In addition, based on the restriction in the number of cases, we studied 26 samples. Results: In this study, a phylogenetic distribution of 26 Iranian isolates was determined using a neighbor-joining method. The revealed that all isolates belonged to Genotype I (Clade I). Conclusions: It is shown that our finding is in concordance with previous studies in Iran. It can be concluded that the strain of HDV being spread in Iran belongs to Genotype 1. This study is in concordance with previous studies in Iran.

Item Type: Article
Keywords: Phylogenetic Analysis Hepatitis Delta Virus Iran molecular epidemiology genotype hdv infection sequence province genome agent Gastroenterology & Hepatology
Divisions:
Page Range: pp. 196-200
Journal or Publication Title: Hepatitis Monthly
Journal Index: ISI
Volume: 9
Number: 3
ISSN: 1735-143X
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/6889

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