Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

A new core promoter mutation and premature stop codon in the S gene in HBV strains from Iranian patients with cirrhosis

(2009) A new core promoter mutation and premature stop codon in the S gene in HBV strains from Iranian patients with cirrhosis. Journal of Viral Hepatitis. pp. 259-264. ISSN 1352-0504

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Abstract

In order to define hepatitis B virus (HBV) mutational patterns in Iran, nucleotide sequences obtained from 91 patients and encompassing the precore, basal core promoter (BCP) and surface (S) regions, were compared. The patients were grouped as asymptomatic carriers, chronic active hepatitis or cirrhotic patients. Genotypes and mutations were determined by sequencing and phylogenetic analysis. All strains belonged to genotype D, and most of them to subgenotype D1. All but two strains specified ayw2, one ayw3 and one adw2 determinants. Two deletions of 8- or 20-bp were found in the X region in eight strains, six from patients with chronic active hepatitis. Eight of 21 strains from patients with cirrhosis harboured unusual mutations such as a stop codon at position 69 in the S region or a previously not described mutation in the BCP region ((TC)-T-1761/ATTTG(1766)). All patients infected by strains with the stop codon mutation had detectable HBsAg and high viral load. The accumulation of mutations found in the BCP and S regions in HBV strains from patients with chronic active hepatitis and cirrhosis may predict disease progression in Iranian HBsAg carriers.

Item Type: Article
Keywords: HBV genome hepatitis B virus Iran liver cirrhosis mutation phylogenetic analysis hepatitis-b-virus normal alt levels phylogenetic analysis turkish patients x-protein antigen hbsag prevalence genotypes variants Gastroenterology & Hepatology Infectious Diseases Virology
Divisions:
Page Range: pp. 259-264
Journal or Publication Title: Journal of Viral Hepatitis
Journal Index: ISI
Volume: 16
Number: 4
Identification Number: https://doi.org/10.1111/j.1365-2893.2009.01069.x
ISSN: 1352-0504
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/6911

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