Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Clinical efficacy of sublingual captopril in the treatment of hypertensive urgency

(2009) Clinical efficacy of sublingual captopril in the treatment of hypertensive urgency. Singapore Medical Journal. pp. 400-402. ISSN 0037-5675

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Abstract

Introduction: This study aimed to evaluate the response rate, clinical efficacy and onset of action of sublingual captopril in patients diagnosed with hypertensive urgency. Methods: In this cross-sectional study, 101 (67 female and 34 male) patients with a diagnosis of hypertensive urgency (systolic pressure greater than or equal to 180 mmHg and/or diastolic pressure greater than or equal to 110 mmHg, and no findings of target organ damage) were included. Sublingual captopril (25 mg) was administered and the blood pressure was measured during a follow-up period of 120 minutes. Results: After 60 minutes, an ideal decrease (25 percent of the initial blood pressure) was detected in 54 patients (53.5 percent). An additional 25 mg of sublingual captopril was administered to the remaining 47 patients (46.5 percent). Of these, 19 (18.8 percent) did not respond even to the second dose of sublingual captopril. These non-responders consisted of patients who were taking multidrug antihypertensive regimens before presentation due to hypertensive urgency. No serious side effect was recorded during the study period. Conclusion: Sublingual captopril can be used as an effective, easily applicable and safe treatment in the management of hypertensive urgency for 120 minutes for those who do not receive multidrug antihypertensive regimens.

Item Type: Article
Keywords: captopril hypertension hypertensive urgency sublingual captopril nifedipine management crises emergencies mortality General & Internal Medicine
Divisions:
Page Range: pp. 400-402
Journal or Publication Title: Singapore Medical Journal
Journal Index: ISI
Volume: 50
Number: 4
ISSN: 0037-5675
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/6914

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