(2018) Long non-coding RNA linc00987 may function as a tumor suppressor in lung adenocarcinoma version 1; peer review: 1 approved with reservations, 1 not approved. F1000Research. ISSN 20461402 (ISSN)
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Abstract
Long non-coding RNAs (lncRNAs) are a group of transcripts over 200 nucleotides in length that do not code for proteins. The association of the dysregulation of numerous lncRNAs with several malignancies, including lung cancer, has been frequently reported. This study aims to inspect the association of genomic and transcriptomic alterations to the lncRNA LINC00987 with lung adenocarcinoma, a subtype of lung cancer, using a bioinformatic approach. To this end, we used three publically available online databases, cBioPortal, the International Cancer Genome Consortium Data Portal and the GEPIA web server. In short, our results demonstrated that LINC00987 expression might have a tumor suppressive role in lung adenocarcinoma and levels of expression could be of prognostic value for this cancer type. © 2018 Salavaty A et al.
| Item Type: | Article |
|---|---|
| Keywords: | Bioinformatics Genotranscriptomic analysis LINC00987 Lung adenocarcinoma Tumor suppressor lncRNA long untranslated RNA Article controlled study down regulation gene deletion gene dosage gene expression gene function gene identification genome analysis human mutational analysis predictive value RNA analysis somatic mutation tumor suppressor gene |
| Divisions: | |
| Journal or Publication Title: | F1000Research |
| Journal Index: | Scopus |
| Volume: | 7 |
| Identification Number: | https://doi.org/10.12688/F1000RESEARCH.14785.1 |
| ISSN: | 20461402 (ISSN) |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.bmsu.ac.ir/id/eprint/701 |
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