Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Sequence analysis of mitochondrial DNA hypervariable regions: An approach to personal identification

(2007) Sequence analysis of mitochondrial DNA hypervariable regions: An approach to personal identification. Archives of Medical Research. pp. 345-349. ISSN 0188-4409

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Abstract

Background. Mitochondrial DNA (mtDNA) sequence analysis of the hypervariable control region has been shown to be an effective tool for personal identification. The high copy and maternal mode of inheritance make mtDNA analysis particularly useful when old samples or degradation of biological samples prohibits the detection of nuclear DNA analysis. Methods. This study reports mtDNA polymorphisms in both HV1 and HV2 of the non-coding D-loop region from 30 Iranian persons (10 unrelated families in three sequential maternal generations). Results. Eighty one polymorphic nucleotide positions were found, 32 in HV1 and 49 in HV2. The sequence of HV1 and HV2 and the occurred polymorphism were completely similar in each family, except for heteroplasmy in five positions ill HV2. The average numbers of nucleotide differences between families were 5.2 nucleotides in HV1 and 2.8 nucleotides in HV2. Conclusions. We expect eight nucleotide differences in sequence of both HV1 and HV2 in two unknown, unrelated Iranian samples. (C) 2007 IMSS. Published by Elsevier Inc.

Item Type: Article
Keywords: mitochondrial DNA hypervariable regions forensic science polymorphism mtdna polymorphisms individuals extraction database Research & Experimental Medicine
Divisions:
Page Range: pp. 345-349
Journal or Publication Title: Archives of Medical Research
Journal Index: ISI
Volume: 38
Number: 3
Identification Number: https://doi.org/10.1016/j.arcmed.2006.10.011
ISSN: 0188-4409
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/7178

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