Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Ascorbic acid antagonizes nicotine-induced place preference and behavioral sensitization in mice

(2007) Ascorbic acid antagonizes nicotine-induced place preference and behavioral sensitization in mice. European Journal of Pharmacology. pp. 42-48. ISSN 0014-2999

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Abstract

In the present study, the influence of ascorbic acid on the nicotine-induced behavioral sensitization and conditioned place preference was investigated in mice. In the place preference paradigm, intraperitoneal (i.p.) nicotine (1 and 1.5 mg/kg, three drug sessions) but not ascorbic acid (1, 10, 100 and 1000 mg/kg) administration induced place preference. Ascorbic acid administration (10, 100 and 1000 mg/kg, i.p.) reduced both the acquisition and expression of nicotine-induced place conditioning. Locomotor sensitization in mice was produced by intraperitoneal injection of nicotine (0.25 mg/kg) for 7 consecutive days. On the 9th day of the experiments, activity of the mice was recorded after challenge with nicotine (0.1 mg/kg, i.p.). Ascorbic acid (10, 100 and 1000 mg/kg, i.p.) was injected 20 min before each injection of nicotine (acquisition of sensitization) or acutely 20 min before a challenge nicotine injection (expression of sensitization). It was shown that ascorbic acid attenuated the acquisition of nicotine sensitization in a dose-independent manner but the expression of nicotine-induced sensitization was not affected by ascorbic acid. In conclusion, it seems that ascorbic acid may interfere with nicotine-induced place preference and behavioral sensitization in mice. (c) 2007 Elsevier B.V. All rights reserved.

Item Type: Article
Keywords: nicotine ascorbic acid place preference behavioral sensitization (mice) freely moving rats nucleus-accumbens nitric-oxide dopamine release smoking striatum vitamin smokers binding brain Pharmacology & Pharmacy
Divisions:
Page Range: pp. 42-48
Journal or Publication Title: European Journal of Pharmacology
Journal Index: ISI
Volume: 560
Number: 1
Identification Number: https://doi.org/10.1016/j.ejphar.2006.12.019
ISSN: 0014-2999
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/7182

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