Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Combined passive and active immunoprophylaxis for preventing perinatal transmission of the hepatitis B virus in infants born to HBsAg positive mothers in comparison with vaccine alone

(2006) Combined passive and active immunoprophylaxis for preventing perinatal transmission of the hepatitis B virus in infants born to HBsAg positive mothers in comparison with vaccine alone. Hepatology Research. pp. 265-271. ISSN 1386-6346

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Abstract

Background: In order for liver cirrhosis and hepatocellular carcinoma not to be inflicted upon in infants' lifetime, it is essential to prevent hepatitis B virus (HBV) infection in them. Objectives: The aim of this study is to reveal the efficacy of passive and active immunoprophylaxis in preventing perinatal transmission of HBV in Iran. Study design: In this cohort study with historical controls, 823 children born to the HBsAg positive mothers were evaluated. Out of this number, 638 had received neither hepatitis B (HB) vaccine nor hepatitis B immune globulin ( HBIG) and aged more than 16 years (n = 481, group 1) or 16 years or less ( n = 157, group 2). The other 125 persons had received only HB vaccine ( group 3), and 60 neonates received both HB vaccine and HBIG ( group 4). Results: The prevalence of HBsAg in groups 1, 2, 3 and 4 was 56.1, 40.3, 12.6, and 3.6, respectively. The prevalence of anti-HBsAb had a significantly descending rate in groups 4 ( 85.7), 3 (68.8), 2 (33.3), and 1 (21.8), respectively. Conclusions: The addition of HBIG to recombinant vaccine will significantly increase the protection against HBV infection in comparison with HB vaccine alone. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

Item Type: Article
Keywords: hepatitis B recombinant hepatitis B vaccine immunogenecity hepatitis B immune globulin infant protective efficacy carrier mothers e-antigen hbeag immunogenicity children state gene Gastroenterology & Hepatology
Divisions:
Page Range: pp. 265-271
Journal or Publication Title: Hepatology Research
Journal Index: ISI
Volume: 36
Number: 4
Identification Number: https://doi.org/10.1016/j.hepres.2006.08.001
ISSN: 1386-6346
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/7214

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