Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Eradication rate of Helicobacter pylori in dyspeptic patients

(2005) Eradication rate of Helicobacter pylori in dyspeptic patients. Medical Science Monitor. CR193-CR195. ISSN 1643-3750

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Abstract

Background:The eradication of Helicobacter plori (HP) is dependent on several bacteriologic and geographic variables. Multiple-drug regimens have been tried in order to eradicate HPi; however, the optimal drug has not yet been found. Material/Methods: In this single-blind, randomized clinical trial, 245 dyspeptic patients with positive rapid urease test's or positive cultures for HP were entered in the study and randomly treated with one of 3 drug regimens A, B, or C for 14 days. Each regimen was administered to 76 patients. Regimen A consisted of orneprazole 20 mg bid + bismuth subcitrate 120 mg 2 tab. bid + metronidazole 250 mg 2 tab. bid + tetracycline 250 mg 2 cap. bid Regmien B consisted of orneprazole 20 mg bid + bismuth subcitrate 120 mg 2 tab. bid + furazolidone 100 mg 2 tab. bid + tetracycline 250 mg 2 cap. bid Regimen C consisted of orneprazole 20 mg bid + bismuth subcitrate 120 mg 2 tab. bid + ciprofloxacin 500 mg bid. A urea breath test was performed 1-2 months after eradication. Results: Of the 245 patients, 228 completed their treatment course. 57 were male and 43 female. Eradication rates were 76.3, 68.4, and 67.1 in groups A, B, and C, respectively (P=0.05). The eradication rate of drug regimen A was greater than B in males (86 vs. 63; p < 0.05), and that of B was greater than C in females (76.7 vs. 53.6; P < 0.05). Conclusions: The therapeutic regimen containing ciprofloxacin is preferable, although all drug regimens were less effective in Iran than in other parts of the world.

Item Type: Article
Keywords: Helicobacter pylori eradication treatment ranitidine bismuth citrate plus clarithromycin quadruple therapy triple therapy tetracycline metronidazole omeprazole efficacy ciprofloxacin tinidazole Research & Experimental Medicine
Divisions:
Page Range: CR193-CR195
Journal or Publication Title: Medical Science Monitor
Journal Index: ISI
Volume: 11
Number: 4
ISSN: 1643-3750
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/7268

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