Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Role of nitric oxide in the acquisition and expression of apomorphine- or morphine-induced locomotor sensitization

(2003) Role of nitric oxide in the acquisition and expression of apomorphine- or morphine-induced locomotor sensitization. European Journal of Pharmacology. pp. 205-213. ISSN 0014-2999

Full text not available from this repository.

Official URL: http://apps.webofknowledge.com/InboundService.do?F...

Abstract

In the present study, the effects of L-arginine, a nitric oxide (NO) precursor, and N-G-nitro-L-arginine methyl ester (L-NAME), a nitric oxide synthase (NOS) inhibitor, on apomorphine- or morphine-induced locomotor sensitization in male albino mice were investigated. Our data showed that subcutaneous (s.c.) injection of apomorphine (2 - 10 mg/kg) or morphine sulphate (5 - 50 mg/kg) significantly increased locomotor behaviour in a dose-dependent manner. Intraperitoneal (i.p.) administration of L-arginine (100 mg/kg) increased locomotor activity, whereas L-NAME (20 mg/kg) decreased it. L-Arginine and L-NAME increased and decreased apomorphine- or morphine-induced locomotions, respectively. The locomotor behavioural response was enhanced in mice pretreated with apomorphine (2 mg/kg, daily x 3 days) or morphine (10 mg/kg, daily x 3 days) alone, indicating that sensitization had developed. Administration of L-arginine 30 min before each of three daily doses of apomorphine or morphine increased the development of sensitization, while administration of L-NAME 30 min before each of three daily doses of apomorphine or morphine decreased the acquisition of sensitization induced by apornorphine or morphine. Administration of L-arginine significantly increased and L-NAME significantly and dose-dependently decreased the expression of both apomorphine- and morphine-induced sensitization. The results indicate that NO may be involved in the acquisition and expression of apomorphine- or morphine-induced sensitization. (C) 2003 Elsevier B.V. All rights reserved.

Item Type: Article
Keywords: apomorphine morphine nitric oxide (NO) L-arginine L-NAME (N-G-nitro-L-arginine methyl ester) locomotor activity sensitization (mouse) ventral tegmental area conditioned place preference behavioral sensitization nucleus-accumbens extracellular dopamine l-arginine synthase inhibitors striatal dopamine reverse tolerance h-3 dopamine Pharmacology & Pharmacy
Divisions:
Page Range: pp. 205-213
Journal or Publication Title: European Journal of Pharmacology
Journal Index: ISI
Volume: 482
Number: 1-3
Identification Number: https://doi.org/10.1016/j.ejphar.2003.10.006
ISSN: 0014-2999
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/7292

Actions (login required)

View Item View Item