Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Involvement of dopamine D2 receptors of the central amygdala on the acquisition and expression of morphine-induced place preference in rat

(2002) Involvement of dopamine D2 receptors of the central amygdala on the acquisition and expression of morphine-induced place preference in rat. Pharmacology Biochemistry and Behavior. pp. 187-197. ISSN 0091-3057

Full text not available from this repository.

Official URL: http://apps.webofknowledge.com/InboundService.do?F...

Abstract

In the present study, the effects of intra-central amygdala (CeA) injections of dopamine (DA) D2-like receptor agonist and antagonist on the acquisition and expression of morphine-induced place preference in male Wistar rats have been investigated. Subcutaneous administration of different doses of morphine sulphate (0.5-10 mg/kg) produced a dose-dependent conditioned place preference (CPP). Using a 3-day schedule of conditioning, it was found that the DA D2/D3 receptor agonist, quinpirole (0.3-3 mug/rat), or the DA D2 receptor antagonist, sulpiride (0.04-5 mug/rat), did not produce a significant place preference or place aversion. Intra-CeA administration of quinpirole (0.3 and 1 mug/rat) with an ineffective dose of morphine (0.5 mg/kg) elicited a significant CPP. On the other hand, quinpirole (0.3 mug/rat injection into the CeA induced CPP in combination with the lower doses of morphine (0.5 and 2.5 mg/kg), but decreased the response of higher dose (7.5 mg/kg) of morphine. This response of quinpirole was attenuated by sulpiride (0.2 mug/rat). Sulpiride by itself (0.04-5 mug/rat) reduced the acquisition of morphine (7.5 mg/kg)-induced place preference. The administration of the higher dose of sulpiride (1 and 5 mug/rat) or the higher dose of quinpirole (3 mug/rat) during acquisition decreased the locomotor activity of the animals on the testing days. The injection of the low dose of quinpirole (0.3 mug/rat) on the test day reduced the expression of morphine-induced CPP, but the high dose of quinpirole (3 mug/rat) potentiated this expression. The administration of sulpiride (5 mug/rat) attenuated the quinpirole response. The injection of sulpiride (1 and 5 mug/rat) abolished the expression of morphine-induced CPP. It is concluded that the CeA DA D2-like receptors may play an active role in morphine reward. (C) 2002 Elsevier Science Inc. All rights reserved.

Item Type: Article
Keywords: dopamine D2 receptors morphine quinpirole sulpiride conditioned place preference central amygdala rat repeated d-amphetamine nucleus-accumbens locomotor-activity d-3 receptors cns sites brain reward antagonists lesions system Behavioral Sciences Neurosciences & Neurology Pharmacology & Pharmacy
Divisions:
Page Range: pp. 187-197
Journal or Publication Title: Pharmacology Biochemistry and Behavior
Journal Index: ISI
Volume: 74
Number: 1
Identification Number: https://doi.org/10.1016/s0091-3057(02)00989-9
ISSN: 0091-3057
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/7361

Actions (login required)

View Item View Item