Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Childhood physical abnormalities following paternal exposure to sulfur mustard gas in Iran: A case-control study

(2010) Childhood physical abnormalities following paternal exposure to sulfur mustard gas in Iran: A case-control study. Conflict and Health. ISSN 17521505 (ISSN)

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Abstract

Background: Mustard gas, a known chemical weapon, was used during the Iran-Iraq war of 1980-1988. We aimed to determine if exposure to mustard gas among men was significantly associated with abnormalities and disorders among progenies. Methods. Using a case-control design, we identified all progenies of Sardasht men (exposed group, n = 498), who were born at least nine months after the exposure, compared to age-matched controls in Rabat, a nearby city (non-exposed group, n = 689). We conducted a thorough medical history, physical examination, and appropriate paraclinical studies to detect any physical abnormality and/or disorder. Given the presence of correlated data, we applied Generalized Estimating Equation (GEE) multivariable models to determine associations. Results: The overall frequency of detected physical abnormalities and disorders was significantly higher in the exposed group (19 vs. 11, Odds Ratio OR 1.93, 95% Confidence Interval CI, 1.37-2.72, P = 0.0002). This was consistent across sexes. Congenital anomalies (OR 3.54, 95% CI, 1.58-7.93, P = 0.002) and asthma (OR, 3.12, 95% CI, 1.43-6.80, P = 0.004) were most commonly associated with exposure. No single abnormality was associated with paternal exposure to mustard gas. Conclusion: Our study demonstrates a generational effect of exposure to mustard gas. The lasting effects of mustard gas exposure in parents effects fertility and may impact child health and development in the long-term. © 2010Abolghasemi et al; licensee BioMed Central Ltd.This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Item Type: Article
Divisions:
Journal or Publication Title: Conflict and Health
Journal Index: Scopus
Volume: 4
Number: 1
Identification Number: https://doi.org/10.1186/1752-1505-4-13
ISSN: 17521505 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/750

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