Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Effect of TGFβ1 and TIMP2 on disease activity in asthma and COPD

(2010) Effect of TGFβ1 and TIMP2 on disease activity in asthma and COPD. Iranian Journal of Allergy, Asthma and Immunology. pp. 79-86. ISSN 17351502 (ISSN)

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Abstract

The process of bronchial tissue repair/remodeling depends on balance between production and degradation achieves the regulation of extracellular matrix turnover. We designed this study to evaluate relation between Transforming Growth Factor β1 (TGFβ1) and Tissue Inhibitory of Metaloproteinase 2 (TIMP2) as two main tissue mediators on activity and reversibility of asthma and chronic obstructive pulmonary disease (COPD). In a cross sectional study we evaluated TIMP2 and TGFβ1 expression in two groups of 29 asthmatic (14 males and 15 females) and 13 male COPD patients using semi-quantitative PCR on induced sputum samples. The relation between TIMP2 and TGFβ1 and PFT indices and disease free period were assessed. The COPD patients with raised expression of both TGFβ1 and TIMP2 had better pulmonary function test (PFT) indices and also longer disease free period. In contrast patients with chronic asthma could remain in well pulmonary function status with raised TIMP2 and decreased TGFβ1 expression. We supposed that underlying inflammatory process is the main reason for the different effect of cytokines in asthma and COPD. It raises concern about critical role of corticosteroids consumption on various cytokines expression. Furthermore TGFβ1 may be served as a biomarker in sputum for assessing disease activity and evidence based prescribing corticosteroids in patients with COPD and asthma. Copyright© 2010, Iranian Journal of Allergy, Asthma and Immunology. All rights reserved.

Item Type: Article
Keywords: Asthma COPD TGFβ1 TIMP2 bronchodilating agent corticosteroid derivative tissue inhibitor of metalloproteinase 2 transforming growth factor beta1 adult article chronic obstructive lung disease clinical article clinical assessment cross-sectional study disease activity disease free interval female human lung function test male polymerase chain reaction protein expression sputum analysis airway remodeling genetics maximal expiratory flow middle aged physiology Cross-Sectional Studies Humans Maximal Expiratory Flow Rate Pulmonary Disease, Chronic Obstructive Tissue Inhibitor of Metalloproteinase-2
Divisions:
Page Range: pp. 79-86
Journal or Publication Title: Iranian Journal of Allergy, Asthma and Immunology
Journal Index: Scopus
Volume: 9
Number: 2
ISSN: 17351502 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/767

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