Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

The effects of Taraxacum officinale L. and Berberis vulgaris L. root extracts on carbon tetrachloride induced liver toxicity in rats

(2010) The effects of Taraxacum officinale L. and Berberis vulgaris L. root extracts on carbon tetrachloride induced liver toxicity in rats. Journal of Medicinal Plants. pp. 45-52. ISSN 16840240 (ISSN)

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Abstract

Background: Taraxacum officinale and Berberis vulgaris have long been used as herbal remedies for treatment of a variety of complaints including liver dysfunction and gallbladder disease. However scientifically reliable data are needed to verify their minimum effective doses. Objective: In present study, the effects of Taraxacum officinale L. and Berberis vulgaris L. root extracts at the different doses 10, 20 and 30 times higher than average dose (THD) used in traditional systems of medicines were tested against carbon tetrachloride (CCl4) induced liver toxicity in rats. Methods: The root extracts of T. officinale at doses of 250, 500 and 750 mg/kg/day and B. vulgaris at doses of 300, 600 and 900 mg/kg/day, relative to 10, 20 and 30 THD average doses used in traditional systems of medicines were prepared by dissolving dry extracts in 5 dimethvl sulfoxide in distilled water. Eighty male Wistar rats, 5 months old, were divided in 8 groups of 10 rats each. Liver intoxication was induced in 7 groups by intraperitoneal injection of 1 ml/kg of 1:1 CCl4 in olive oil for two successive days. One group was kept as control and six different doses of medicinal plants . extracts were administered to six groups simultaneously with CCl4 administration. After three days the serum levels of ALT, AST and ALP, liver tissue glutathione level and catalase activities as well as liver tissue microvesicular steatosis and pericentral coagulation necrosis were determined. Results: In control group the blood levels of ALT, AST, ALP and liver tissue injury were increased whereas the serum GSH level and catalase activity decreased significantly after 3 days of beginning of carbon tetrachloride liver toxicity as compared to normal group. In T. officinale treated group at the dose of 750 mg/kg/day, the serum ALT and ALP levels and in B. vulgaris at the dose of 900 mg/kg/day, the serum ALP levels reduced significantly as compared to control group. The liver micro vesicular steatosis was inhibited significantly in both groups at the doses of 30 THD as compared to control group. Conclusion: In the present study administration of T. officinale and B. vulgaris root extracts at with 30 THD ameliorated CCl 4 induced liver damage.

Item Type: Article
Keywords: Berberis vulgaris Carbon tetrachloride Liver toxicity Medicinal plants Taraxacum officinale alanine aminotransferase alkaline phosphatase aspartate aminotransferase berberis vulgaris extract catalase glutathione plant extract taraxacum officinale extract unclassified drug alanine aminotransferase blood level alkaline phosphatase blood level animal experiment animal model animal tissue antioxidant activity article aspartate aminotransferase blood level Berberis controlled study dandelion enzyme activity fatty liver histopathology liver injury liver necrosis liver protection male nonhuman plant root protein blood level rat Rattus Rattus norvegicus
Divisions:
Page Range: pp. 45-52
Journal or Publication Title: Journal of Medicinal Plants
Journal Index: Scopus
Volume: 9
Number: SUPPL
ISSN: 16840240 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/780

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