Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

A genomic catalog of Earth’s microbiomes

(2020) A genomic catalog of Earth’s microbiomes. Nature Biotechnology. ISSN 10870156 (ISSN)

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The reconstruction of bacterial and archaeal genomes from shotgun metagenomes has enabled insights into the ecology and evolution of environmental and host-associated microbiomes. Here we applied this approach to >10,000 metagenomes collected from diverse habitats covering all of Earth’s continents and oceans, including metagenomes from human and animal hosts, engineered environments, and natural and agricultural soils, to capture extant microbial, metabolic and functional potential. This comprehensive catalog includes 52,515 metagenome-assembled genomes representing 12,556 novel candidate species-level operational taxonomic units spanning 135 phyla. The catalog expands the known phylogenetic diversity of bacteria and archaea by 44 and is broadly available for streamlined comparative analyses, interactive exploration, metabolic modeling and bulk download. We demonstrate the utility of this collection for understanding secondary-metabolite biosynthetic potential and for resolving thousands of new host linkages to uncultivated viruses. This resource underscores the value of genome-centric approaches for revealing genomic properties of uncultivated microorganisms that affect ecosystem processes. © 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.

Item Type: Article
Keywords: Agricultural robots Ecology Genes Metabolism Metabolites Viruses Agricultural soils Comparative analysis Engineered environments Interactive exploration Metabolic modeling Operational taxonomic units Phylogenetic diversity Secondary metabolites Bacteria archaeon article habitat human metagenome microbiome microorganism nonhuman sea soil virus
Journal or Publication Title: Nature Biotechnology
Journal Index: Scopus
Identification Number:
ISSN: 10870156 (ISSN)
Depositing User: مهندس مهدی شریفی

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