Abstract

Crimean-Congo Hemorrhagic Fever Virus (CCHFV) is an important human pathogen, which is the cause of a tick-borne illness occurring in different continent including Africa, Asia and Europe. CCHF could be seen as a sudden onset of high fever, chills, severe headache and gastrointestinal disorders, such as nausea, vomiting and diarrhea. Hemorrhagic manifestations can occur in severe cases too. The virus could be transmitted to human, when exposure to ticks, particularly those in the genus Hyalomma, happened, or direct contact with virus-infected animals or people who infected by virus. Unfortunately, many people are infected a cross the world and a few of them either as nosocomonal infection were died. At the present time no vaccine available to protect human or animal from infection. Only health measure has been recommended to prevent the infection. Supportive treatment also was recommended to management of the patient. This article reviews the history, epidemiology, ecology, clinical features, pathogenesis, diagnosis and treatment of CCHF. © 2008 Academic Journals Inc.