Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Angiotensin-converting enzyme genotype and late respiratory complications of mustard gas exposure

(2008) Angiotensin-converting enzyme genotype and late respiratory complications of mustard gas exposure. BMC Pulmonary Medicine. ISSN 14712466 (ISSN)

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Abstract

Background: Exposure to mustard gas frequently results in long-term respiratory complications. However the factors which drive the development and progression of these complications remain unclear. The Renin Angiotensin System (RAS) has been implicated in lung inflammatory and fibrotic responses. Genetic variation within the gene coding for the Angiotensin Converting Enzyme (ACE), specifically the Insertion/Deletion polymorphism (I/D), is associated with variable levels of ACE and with the severity of several acute and chronic respiratory diseases. We hypothesized that the ACE genotype might influence the severity of late respiratory complications of mustard gas exposure. Methods: 208 Kurdish patients who had suffered high exposure to mustard gas, as defined by cutaneous lesions at initial assessment, in Sardasht, Iran on June 29 1987, underwent clinical examination, spirometric evaluation and ACE Insertion/Deletion genotyping in September 2005. Results: ACE genotype was determined in 207 subjects. As a continuous variable, FEV1 predicted tended to be higher in association with the D allele 68.03 ± 20.5, 69.4 ± 21.4 and 74.8 ± 20.1 for II, ID and DD genotypes respectively. Median FEV1 predicted was 73 and this was taken as a cut off between groups defined as having better or worse lung function. The ACE DD genotype was overrepresented in the better spirometry group (Chi2 4.9 p = 0.03). Increasing age at the time of exposure was associated with reduced FEV1 predicted (p = 0.001), whereas gender was not (p = 0.43). Conclusion: The ACE D allele is associated with higher FEV1 predicted when assessed 18 years after high exposure to mustard gas. © 2008 Hosseini-khalili et al; licensee BioMed Central Ltd.

Item Type: Article
Keywords: dipeptidyl carboxypeptidase mustard gas chemical warfare agent renin adult age distribution allele article controlled study disease severity environmental exposure female forced expiratory volume gene deletion gene insertion genetic association genotype human Iran lung function test major clinical study male prognosis renin angiotensin aldosterone system respiratory tract disease spirometry chemical warfare chemically induced disorder genetic polymorphism genetics Iraq lung disease middle aged Chemical Warfare Agents Humans Lung Diseases Polymorphism, Genetic
Divisions:
Journal or Publication Title: BMC Pulmonary Medicine
Journal Index: Scopus
Volume: 8
Identification Number: https://doi.org/10.1186/1471-2466-8-15
ISSN: 14712466 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/853

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