Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Surgical Suture Assembled with Tadalafil/Polycaprolactone Drug- Delivery for Vascular Stimulation Around Wound: Validated in a Preclinical Model

(2020) Surgical Suture Assembled with Tadalafil/Polycaprolactone Drug- Delivery for Vascular Stimulation Around Wound: Validated in a Preclinical Model. Biointerface Research in Applied Chemistry. pp. 6317-6327. ISSN 2069-5837

[img] Text
Surgical Suture Assembled with TadalafilPolycaprolactone Drug- Delivery for Vascular Stimulation Around Wound Validated in a Preclinical Model.pdf

Download (478kB)

Official URL: http://apps.webofknowledge.com/InboundService.do?F...

Abstract

In this study, a novel Polycaprolactone suture assembled with Tadalafil was investigated to improve wound healing processes via vascular stimulation. Tadalafil/Polycaprolactone (TP) suture was developed by the electrospinning method. The designed suture was characterized by SEM, mechanical properties assessments, tensile strength measurements and the drug release study. For in vivo tests, rats were classified into two study groups. An incision was made on their back skin and they were sutured with TP suture and Polycaprolactone suture as control. Rats were sacrificed at 7 days following surgery for histopathological examinations with Hematoxylin and Eosin staining. Results of Tensile test demonstrated that the lowest tensile strength belonged to 3 and 4 wt and the highest tensile strength belonged to 1 and 2 wt of TP suture. The rate of Tadalafil release showed that the highest drug release was related to 3 and 4 wt which were about 125 to 210 mu g during 15 days. The histopathology revealed that the number of blood vessels, collagen fibers, fibroblast, polymorphonuclear leukocytes, and epithelization was remarkable in Tadalafil/Polycaprolactone group during 7-day. A novel Tadalafil/Polycaprolactone suture improved the processes of wound healing by releasing the Tadalafil drug around the sutured wound and can be used in medical applications.

Item Type: Article
Keywords: Suture Wound Tadalafil Polycaprolactone eluting sutures in-vivo release inhibitors infection tadalafil Chemistry
Page Range: pp. 6317-6327
Journal or Publication Title: Biointerface Research in Applied Chemistry
Journal Index: ISI
Volume: 10
Number: 5
Identification Number: https://doi.org/10.33263/briac105.63176327
ISSN: 2069-5837
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/8543

Actions (login required)

View Item View Item