Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Evaluation of the expression level of Sine oculis homeobox homolog 1 in cervical cancer tissue in comparison with healthy adjacent tissue

(2020) Evaluation of the expression level of Sine oculis homeobox homolog 1 in cervical cancer tissue in comparison with healthy adjacent tissue. Romanian Journal of Military Medicine. pp. 172-176. ISSN 1222-5126

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Abstract

Background and Aim: This study aimed to investigate the expression level of Sine oculis homeobox homolog 1(SIX1) in normal and cancerous cervical tissues. Methods: Real-time PCR was used to evaluate SIX1 expression level in fresh surgically obtained cervical biopsies. Also, cervical specimens were tested for HPV DNA detection by MY09/11, GP5+/6+ nested PCR method. Results: The expression level of SIX1 mRNA in Cervical cancer was markedly higher than in normal cervical tissue (p<0.0001). Moreover, HPV DNA was detected in 100 of cases and 21.05 of controls (P<0.0001). Conclusions: This finding indicates that increased SIX1 expression might be of relevance to the pathogenesis of cervical cancer. Perhaps, studies to find agents that specifically target SIX1, develop novel anti-cancer and anti-metastasis drugs. This idea has to be investigated in future clinical studies.

Item Type: Article
Keywords: cervical cancer SIX1 molecular mechanism pathogenesis expression level epithelial-mesenchymal transition human-papillomavirus six1 metastasis carcinoma ezrin overexpression resistance General & Internal Medicine
Page Range: pp. 172-176
Journal or Publication Title: Romanian Journal of Military Medicine
Journal Index: ISI
Volume: 123
Number: 3
ISSN: 1222-5126
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/8676

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