Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

High Frequency of AdeA, AdeB and AdeC Genes among Acinetobacter baumannii Isolates

(2020) High Frequency of AdeA, AdeB and AdeC Genes among Acinetobacter baumannii Isolates. Iranian Journal of Public Health. pp. 1539-1545. ISSN 2251-6085

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Abstract

Background: Efflux pumps are involved in resistance of Acinetobacter baumannii isolates to antimicrobial agents. AdeABC efflux pump is one of the RND superfamily efflux pump and consists of adeA (membrane fusion), adeB (multidrug transporter) and adeC (outer membrane) genes. In this study, the frequency of adeA, adeB and adeC genes among A. baumannii isolates with resistance to erythromycin, trimethoprim, meropenem and imipenem was investigated. Methods: Overall, 79 strains of A. baumannii were isolated from patients admitted to two major hospitals in Tehran during 2016. Antibiotic susceptibility testing was determined by disc diffusion and microdilution methods according to Clinical and Laboratory Standards Institute (CLSI) guideline. The presence of adeA, adeB and adeC genes was also determined using Multiplex PCR assay. Results: The highest and the lowest resistance among A. baumannii isolates were to trimethoprim (93) and erythromycin (53), respectively. The frequency of adeA, adeB and adeC genes was 96.2, 96.2 and 91.1 degrees A) respectively. There was a significant relationship between imipenem resistance and presence of efflux pump genes (P<0.05). Conclusion: According to the high prevalence of the AdeABC efflux system genes, it may involve in resistance of clinical isolates of A. baumannii to imipenem, especially.

Item Type: Article
Keywords: Acinetobacter baumannii Antibiotic resistance Gene efflux pump antimicrobial resistance carbapenem resistance nosocomial infections new-york spp. epidemiology susceptibility identification prevalence Public, Environmental & Occupational Health
Page Range: pp. 1539-1545
Journal or Publication Title: Iranian Journal of Public Health
Journal Index: ISI
Volume: 49
Number: 8
ISSN: 2251-6085
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/8684

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