Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

The relationship between ANT1 and NFL with autophagy and mitophagy markers in patients with multiple sclerosis

(2020) The relationship between ANT1 and NFL with autophagy and mitophagy markers in patients with multiple sclerosis. Journal of Clinical Neuroscience. pp. 307-312. ISSN 0967-5868

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Abstract

Multiple sclerosis (MS) is the most common inflammatory neurodegenerative disease. Neurofilament light chain (NFL) is a novel adverting biomarker of axonal damage that suggested as a useful assistant in the monitoring of MS patients. It has been shown that the auto/mitophagy associated with MS pathogenesis. In this study, we aimed to study correlation between ATG5 and Parkin, as markers of autophagy and mitophagy respectively, with NFL and ANT1 in serum and cerebrospinal fluid (CSF) in MS subjects. ATG5, Parkin, NFL, and ANT1 levels were measured in a cross-sectional study of 40 MS patients compared with gender, age and BMI matching healthy volunteers. Based on our results, levels of ATG5, Parkin, and NFL significantly were elevated in both serum and CSF of MS patients comparing control individuals (p < 0.0001) but ANT1 levels significantly was decreased in both serum and CSF of MS patients comparing control individuals (p < 0.0001). The correlation indices between NFL ANTI1, ATG5 and Parkin in both case and control groups showed a direct and moderate the correlation between ANTI1 and ATG5 in the CSF level of the control group (r = 0.554, P = 0.011). Our data support the feasibility of quantifying of NFL as a sensitive and clinically meaningful serum/CSF biomarker to follow-up nerve tissue injury in MS condition. (C) 2020 Elsevier Ltd. All rights reserved.

Item Type: Article
Keywords: Multiple sclerosis Autophagy Mitophagy Neurofilament light chain Novel biomarkers neurofilament light-chain disease-activity monitoring autophagy pathogenesis mitochondria guidelines mechanisms diagnosis assays Neurosciences & Neurology
Page Range: pp. 307-312
Journal or Publication Title: Journal of Clinical Neuroscience
Journal Index: ISI
Volume: 78
Identification Number: https://doi.org/10.1016/j.jocn.2020.04.122
ISSN: 0967-5868
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/8685

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