Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

EMAST frequency in colorectal cancer: a meta-analysis and literature review

(2020) EMAST frequency in colorectal cancer: a meta-analysis and literature review. Biomarkers in Medicine. pp. 1021-1030. ISSN 1752-0363

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Abstract

Aim:The prognostic and predictive value of Elevated Microsatellite Alterations at Selected Tetranucleotide (EMAST) has been reported in colorectal cancer (CRC). The prevalence of EMAST in CRC varied across the literature. We conducted a meta-analysis to determine the prevalence of EMAST in CRC.Materials & methods:Three international databases including PubMed, ISI and Scopus were searched to identify related articles that described the frequency of EMAST.Results:Analysis was performed on 16 eligible studies including 4922 patients. The overall EMAST prevalence among CRCs patients was 33 (95 CI: 23-43, I-2 = 98).Conclusion:This study indicated that approximately a third of the CRC patients are diagnosed with EMAST, hereupon EMAST as a prognostic and predictive biomarker should be more studied clinically.

Item Type: Article
Keywords: colorectal neoplasms consensus molecular subtype elevated microsatellite alterations at selected tetranucleotide predictive biomarker prevalence prognostic biomarker elevated microsatellite alterations tetranucleotide repeats instability biomarkers sequences tumors cells Research & Experimental Medicine
Page Range: pp. 1021-1030
Journal or Publication Title: Biomarkers in Medicine
Journal Index: ISI
Volume: 14
Number: 11
Identification Number: https://doi.org/10.2217/bmm-2020-0068
ISSN: 1752-0363
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/8773

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