Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

The correlation of helios and neuropilin-1 frequencies with parkinson disease severity

(2020) The correlation of helios and neuropilin-1 frequencies with parkinson disease severity. Clinical Neurology and Neurosurgery. p. 5. ISSN 0303-8467

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Abstract

Objectives: Parkinson disease (PD), a neurodegenerative disease, has also some immunologic basis in which several regulatory factors, like Helios and Neuropilin-1 (NRP-1) may show some roles in its pathogenesis. We aimed to evaluate the circulatory frequency of T regulatory cells (Tregs) expressing Helios and NRP-1 in PD. Patients and Methods: In this case-control study, 83 patients with PD and 83 healthy controls were enrolled. The diagnosis of PD was accomplished in accordance with clinical diagnostic criteria of the UK Parkinson Disease Society Brain Bank. The modified Hoehn and Yahr (H and Y) were used to measure the severity of PD. Flow cytometry was used to evaluate the circulatory frequency of CD4+CD25+Foxp3+Tregs expressing and Helios and NRP-1 in all participants. Also, correlation of H and Y with such frequencies was evaluated. Results: Our findings showed that frequency of CD4+CD25+Foxp3+Tregs expressing NRP-1 (P= 0.04) and Helios (P= 0.01) in patients with PD was significantly higher than those in healthy subjects. The frequency of Tregs expressing Helios and NRP-1 showed a negative correlation with H and Y criteria and disease duration. Multiple linear regression analysis indicated that the severity of PD is the only effective factor on the frequency of CD4+CD25+Foxp3+NRP-1+Tregs (P= 0.012) and CD4+CD25+FoxP3+ Helios+ Tregs (P= 0.038). Conclusion: Our study showed that the increased frequency of Tregs expressing Helios and NRP-1 is associated with the severity of PD.

Item Type: Article
Keywords: Helios Neuropilin1 Parkinson disease H and Y regulatory t-cells endothelial growth-factor lymph-nodes expression receptor vegfr2 cancer Neurosciences & Neurology Surgery
Page Range: p. 5
Journal or Publication Title: Clinical Neurology and Neurosurgery
Journal Index: ISI
Volume: 192
Identification Number: https://doi.org/10.1016/j.clineuro.2020.105833
ISSN: 0303-8467
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/8843

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