Abstract

Verticinone as a steroidal alkaloid is one of the major active constituents of medicinal herb, Fritillaria imperialis with several pharmacological properties. Present data demonstrate an in vitro assessment of verticinone effects on beta-TC6 pancreatic and C2C12 skeletal muscle cells include cell survival, activities of carbohydrate-hydrolyzing enzymes (alpha-amylase and alpha-glucosidase), levels of insulin secreted into the media, glucose uptake ability, advanced glycation end product (AGEs) include 3-deoxyglucosone, methylglyoxal, and pentosidine levels and the activity of glyoxalase I. Data reveals possible hypoglycemic potential of verticinone, although, the high concentrations of this compound were associated with elevated amount of AGEs and it should be assessed in future investigations. (C) 2019 The Author(s). Published by Elsevier Inc.