Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Insulin resistance in chronic hepatitis B and C

(2006) Insulin resistance in chronic hepatitis B and C. Indian Journal of Gastroenterology. pp. 286-289. ISSN 02548860 (ISSN)

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Aim: To determine whether insulin resistance occurs in patients with chronic hepatitis B (CHB) and chronic hepatitis C (CHC), and its relationship with the presence of liver fibrosis and steatosis. Methods: Untreated patients with CHC (n=60) or CHB (n=40), similar in age, gender, body mass index and waist-hip ratio, were studied. Relationship between anthropometric, biochemical (fasting serum insulin, C-peptide, ferritin, iron, TNF-α, cholesterol, triglyceride, bilirubin, hemoglobin, and platelet concentrations) and liver biopsy (43 CHC and 20 CHB patients) findings was investigated by insulin resistance determined via the homeostasis model assessment (HOMA-IR). Results: The mean fasting serum insulin was 14.9 (11.9) mU/mL in CHC and 21.4 (17.4) in the CHB group (normal range 0.7-9; p=0.049) and mean HOMA-IR was 3.1 (2.6) in CHC versus 4.7 (4.1) in the CHB group (normal range 0.12-4.61; p=0.036) . HOMA-IR was significantly associated with fibrosis stage in the CHC group (p=0.015), but not in the CHB group. Conclusion: Hyperinsulinemia occurs in chronic viral hepatitis B and hepatitis C; insulin resistance is associated with stage of fibrosis in hepatitis C. Copyright © 2006 by Indian Society of Gastroenterology.

Item Type: Article
Keywords: bilirubin C peptide cholesterol ferritin hemoglobin insulin iron triacylglycerol tumor necrosis factor alpha virus DNA adult anthropometry article body mass controlled study female hepatitis B hepatitis C homeostasis human human tissue insulin blood level insulin resistance laboratory test liver biopsy liver fibrosis major clinical study male steatosis waist circumference blood fatty liver genetics genotype Hepatitis C virus liver cirrhosis pathophysiology physiology statistical model virus load DNA, Viral Hepacivirus Hepatitis B, Chronic Hepatitis C, Chronic Humans Linear Models Viral Load
Page Range: pp. 286-289
Journal or Publication Title: Indian Journal of Gastroenterology
Journal Index: Scopus
Volume: 25
Number: 6
ISSN: 02548860 (ISSN)
Depositing User: مهندس مهدی شریفی

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