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Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Epidemiology of hepatitis B, hepatitis C, and human immunodeficiency virus infections in patients with beta-thalassemia in Iran: A multicenter study

(2006) Epidemiology of hepatitis B, hepatitis C, and human immunodeficiency virus infections in patients with beta-thalassemia in Iran: A multicenter study. Archives of Iranian Medicine. pp. 319-323. ISSN 10292977 (ISSN)

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Abstract

Background: Though regular blood transfusion improves the overall survival of patients with β-thalassemia, it carries a definite risk of infection with blood-borne viruses. We carried out this multicenter study to provide epidemiologic data on hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) infection among Iranian β-thalassemic patients. Moreover, HCV infection-associated risk factors were investigated in this population. Methods: Seven hundred and thirty-two patients with β-thalassemia major or β-thalassemia intermedia, selected from five provinces of Iran including Tehran (n = 410), Kerman (n = 100), Qazvin (n = 95), Semnan (n = 81), and Zanjan (n = 46), were enrolled in this study. Using ELISA, their sera were tested for HBsAg, HBcAb, HBsAb, HCVAb, and HIVAb. The positive HCVAb results were confirmed by RIBA-2nd generation. Results: The study sample consisted of 413 males and 319 females, with a mean ± SD age of 17.9 ± 9.0 years. One hundred forty-one (19.3) patients were HCVAb positive; 11 (1.5) were HBsAg positive. No one was HIVAb positive. Univariate analysis showed that β-thalassemia major (P = 0.01), older age (P = 0.001), longer transfusion duration (P = 0.000), HBsAg seropositivity (P = 0.03), and higher serum ferritin level (P = 0.002) were significantly associated with a higher prevalence of HCV. Furthermore, the prevalence of HCV infection dropped significantly after the implementation of blood donors, screening (22.8 vs. 2.6; P = 0.000). Using multivariate analysis, β-thalassemia major (P = 0.002), age (P < 0.001), serum ferritin level (P < 0.001), as well as consumption of unscreened blood (P = 0.003), were independent factors associated with HCV infection. Conclusion: The prevalence of HCV infection is much higher among Iranian β-thalassemic patients as compared with HBV and HIV infections. Routine screening of donated blood for HCV is highly recommended.

Item Type: Article
Keywords: Blood transfusion Hepatitis B Hepatitis C Human immunodeficiency virus Thalassemia ferritin hepatitis B surface antibody hepatitis B surface antigen hepatitis C antibody Human immunodeficiency virus antibody adolescent adult age distribution article beta thalassemia blood donor controlled study enzyme linked immunosorbent assay female ferritin blood level human Human immunodeficiency virus infection infant infection risk Iran major clinical study male multivariate analysis prevalence screening serology thalassemia major univariate analysis beta-Thalassemia Child Child, Preschool HIV Infections Humans Middle Aged Risk Factors
Divisions:
Page Range: pp. 319-323
Journal or Publication Title: Archives of Iranian Medicine
Journal Index: Scopus
Volume: 9
Number: 4
ISSN: 10292977 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/934

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