Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Evaluation of physical, mechanical and biological properties of β-tri-calcium phosphate/Poly-3-hydroxybutyrate nano composite scaffold for bone tissue engineering application

(2021) Evaluation of physical, mechanical and biological properties of β-tri-calcium phosphate/Poly-3-hydroxybutyrate nano composite scaffold for bone tissue engineering application. Materials Technology. pp. 237-249. ISSN 10667857 (ISSN)

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Abstract

Design of a scaffold with convenient mechanical properties to emulate bone structure is a major challenge for bone tissue engineers. In this study, porous ceramic scaffolds containing various weight fractions of nano β-tricalcium phosphate (nβ-TCP) (with a particle size of about 50-70 nm) were prepared by the replication method. Synthesised scaffolds were then coated with poly(3‐hydroxybutyrate) (PHB) for 30 and 60 sec. According to the morphological and mechanical tests, it was determined that synthesised scaffold containing 50 wt. of nβ-TCP with a coating time of 30 sec showed desirable properties in bone tissue engineering. The bioactivity of this scaffold indicated that the bone-like apatite layers were well formed on the nanocomposite scaffold. Cell culture study showed a significant increase in cell proliferation between the coated, uncoated and control sample after 5 days of cell culturing. The results confirm that this nanocomposite scaffold has good potential for bone tissue engineering applications. © 2020 Informa UK Limited, trading as Taylor & Francis Group.

Item Type: Article
Keywords: Nano-β-tricalcium phosphate (nβ-TCP) poly-3-hydroxybutyrate (PHB) scaffold tissue engineering Biomechanics Bone Calcium phosphate Cell culture Cell proliferation Nanocomposites Particle size Phosphate minerals Scaffolds Tissue Transmission control protocol Beta tricalcium phosphate Biological properties Bone tissue engineering Nanocomposite scaffolds Poly3-hydroxybutyrate (PHB) Porous ceramic scaffolds Replication method Tri-calcium phosphates Scaffolds (biology)
Page Range: pp. 237-249
Journal or Publication Title: Materials Technology
Journal Index: Scopus
Volume: 36
Number: 4
Identification Number: https://doi.org/10.1080/10667857.2020.1747806
ISSN: 10667857 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/9354

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