Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Multiple potential targets of opioids in the treatment of acute respiratory distress syndrome from COVID-19

(2021) Multiple potential targets of opioids in the treatment of acute respiratory distress syndrome from COVID-19. J Cell Mol Med. pp. 591-595. ISSN 1582-1838 (Print) 1582-1838

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Abstract

COVID-19 can present with a variety of clinical features, ranging from asymptomatic or mild respiratory symptoms to fulminant acute respiratory distress syndrome (ARDS) depending on the host's immune responses and the extent of the associated pathologies. This implies that several measures need to be taken to limit severely impairing symptoms caused by viral-induced pathology in vital organs. Opioids are most exploited for their analgesic effects but their usage in the palliation of dyspnoea, immunomodulation and lysosomotropism may represent potential usages of opioids in COVID-19. Here, we describe the mechanisms involved in each of these potential usages, highlighting the benefits of using opioids in the treatment of ARDS from SARS-CoV-2 infection.

Item Type: Article
Keywords: Analgesics, Opioid/administration & dosage/*therapeutic use COVID-19/complications/*drug therapy/*etiology Cytokine Release Syndrome/drug therapy/virology Dyspnea/drug therapy/etiology Humans Immunomodulation/drug effects/physiology Lysosomes/drug effects Receptors, Opioid/immunology Respiratory Distress Syndrome/*drug therapy *Ards *Covid-19 *cytokine storm *dyspnoea *immunomodulation *opioids
Page Range: pp. 591-595
Journal or Publication Title: J Cell Mol Med
Journal Index: Pubmed
Volume: 25
Number: 1
Identification Number: https://doi.org/10.1111/jcmm.15927
ISSN: 1582-1838 (Print) 1582-1838
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/9383

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