Abstract

OBJECTIVES: The knowledge about molecular pathway of traumatic pain relief is less documented. The systematic review study aimed to identify the genes and molecular pathways associated to various traumatic pain. METHODS: The online databases such as EMBASE, MEDLINE, PubMed, Cochrane Library, International Clinical Trials Registry Platform, and Clinical Trials, Google Scholar, Wiley, ISI Web of Knowledge, and Scopus were searched. Two review authors separately searched and screened the titles and abstracts of all records, and the third expert reviewer author resolved disagreement of them. Information regarding study's design, various trauma injuries, types of genes, and the molecular pathways were recorded. The data about genes and molecular pathways obtained via GeneCards®: The Human Gene Database (https://www.genecards.org). RESULTS: Studies about trauma injuries types regarding nerve and Spinal Cord Injuries (SCIs) (12 records), Hypertrophic scar with Severe Pain (one record), severe post-traumatic musculoskeletal pain (MSP) (one record), and orthopedic trauma (one record) were included. The main molecular pathways including immune system, apoptosis, and death receptor signaling, T-cell antigen receptor (TCR) signaling pathway, oxidative stress, interleukin(s) mediated signaling pathway, biological oxidations, metabolic pathways (especially amino acid metabolism and amino group), focal adhesion, the proliferation of vascular, epithelial, and connective tissue cells, angiogenesis and neural development were identified. CONCLUSION: The immune system, apoptosis, and metabolic pathways are crucial for understanding the roles of genes in traumatic pain. It is recommended that these identified pathways and related genes can be a therapeutically target for pain management in trauma injuries patients. Also, pathways and related genes should be considered discriminately regarding various types of trauma injuries.