Repository of Research and Investigative Information

Repository of Research and Investigative Information

Baqiyatallah University of Medical Sciences

Diagnostic accuracy and validity of serological and molecular tests for Hepatitis B and C: A review article

(2021) Diagnostic accuracy and validity of serological and molecular tests for Hepatitis B and C: A review article. Curr Pharm Biotechnol. ISSN 1389-2010

Full text not available from this repository.

Abstract

INTRODUCTION: Hepatitis B and C viruses are among the leading causes of health problems globally, and their early diagnosis and treatment are very important. Thereby, this study aimed to evaluate the validity and reliability of functional diagnostic tests to detect hepatitis B and C viruses in the clinical setting and compare them with each other. MATERIALS AND METHODS: In this review article, we have searched major online databases, including PubMed and EMBASE. Forty-two retrieved articles, published between January 2000 and January 2020, are summarized in this review. RESULTS: Immunoassay approaches are general techniques for identifying pathogenic agents, among which ELISA is the gold standard for the detection of HBsAg. While serological techniques are not conclusive, Molecular assays are really important because of the high sensitivity to detect chronic hepatitis B without HBeAg, in which viral loads are very low. Biosensors have higher selectivity and sensitivity and faster responses compared to other methods. CONCLUSIONS: This study suggests that all molecular, serological, and biotechnological assays have advantages and disadvantages for diagnosing hepatitis B and C viruses, depending on the condition. Therefore, we should choose one of them in regards to time, cost, and laboratory equipment along with the clinical symptoms.

Item Type: Article
Keywords: Hepatitis B virus diagnostic tests hepatitis C virus molecular methods. rapid Point-of-care test serological assays
Journal or Publication Title: Curr Pharm Biotechnol
Journal Index: Pubmed
Identification Number: https://doi.org/10.2174/1389201022666210719162802
ISSN: 1389-2010
Depositing User: مهندس مهدی شریفی
URI: http://eprints.bmsu.ac.ir/id/eprint/9432

Actions (login required)

View Item View Item