(2021) Effect of Sodium Cyanide-induced Tissue Hypoxia on Reproductive Capability of Male Mice and the Protective Effect of Ethyl Pyruvate. Arch Razi Inst. pp. 323-333. ISSN 0365-3439 (Print) 0365-3439
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Effect of Sodium Cyanide-induced Tissue Hypoxia on Reproductive Capability of Male Mice and the Protective Effect of Ethyl Pyruvate.pdf Download (703kB) |
Abstract
The present study aimed to assess the effect of tissue hypoxia induced by sodium cyanide (NaCN) on male mice fertility and the protective role of ethyl pyruvate (EP). A number of 30 adult mice were assigned to three groups: 1) a control group, 2) a treatment group treated with 2 mg/kg of NaCN, and 3) a treatment group treated with 2 mg/kg of NaCN, along with 40 mg/kg EP (NaCN+EP). After 35 days, animals were anesthetized and serum, sperm, and tissue samples were taken. The results demonstrated a significant decrease in sperm quality, reproduction potency, and anti-oxidant potential, as well as an increase in lipid peroxidation in the NaCN group (p <0.05). Moreover, the use of EP effectively restrained the disastrous effects of tissue hypoxia. It can be concluded that EP can moderate the complications resulting from tissue-hypoxia that is related to testes parameters.
| Item Type: | Article |
|---|---|
| Keywords: | Animals *Hypoxia/chemically induced/veterinary Male Mice *Pyruvates Reproduction Sodium Cyanide *Cyanide *Ethyl pyruvate *Mice *Reproduction potency *Sodium *Tissue hypoxia |
| Page Range: | pp. 323-333 |
| Journal or Publication Title: | Arch Razi Inst |
| Journal Index: | Pubmed |
| Volume: | 76 |
| Number: | 2 |
| Identification Number: | https://doi.org/10.22092/ari.2020.126806.1362 |
| ISSN: | 0365-3439 (Print) 0365-3439 |
| Depositing User: | مهندس مهدی شریفی |
| URI: | http://eprints.bmsu.ac.ir/id/eprint/9467 |
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